Aquí una lista de nuestras mas recientes publicaciones. Puedes descargarlas en pdf haciendo clic en el título de cada una

ALVAREZ A, BRONFMAN F, PEREZ C, VICENTE M, GARRIDO J and INESTROSA NC. Acetylcholinesterase, a senile plaque component, affects the fibrillogenesis of amyloid--peptides. Neurosci. Lett., 201, 49-52, 1995.

BRONFMAN FC, SOTO C, TAPIA L, TAPIA V and INESTROSA NC. Extracellular matrix regulates the amount of the -Amyloid precursor protein and its amyloidogenic fragments. J. Cell. Physiol.,166, 360-369, 1996.

BRONFMAN FC, FERNANDEZ HL and INESTROSA NC. Amyloid precursor protein fragment and acetylcholinesterase increase with cell confluence and differentiation in a neural cell line. Exp. Cell. Res., 229: 93-99, 1996.

BRONFMAN FC, GARRIDO J, ALVAREZ A, MORGAN C and INESTROSA NC. Laminin inhibits amyloid-b peptide fibrillation. Neurosci. Lett.,218, 201-203, 1996.

BRONFMAN FC, ALVAREZ A, GARRIDO J, MORGAN C and INESTROSA NC. Laminin blocks the assembly of wild-type Ab and Dutch variant peptide into Alzheimer’s fibrils. Amyloid 5, 16-23, 1998.

BRONFMAN FC, MOECHARS D and VAN LEUVEN F. Acetylcholinesterase-positive fiber deafferentation and cell shrinkage in the septohippocampal pathway of aged amyloid precursor protein London mutant transgenic mice. Neurobiol. Dis. 7 152-1682000

BRONFMAN FC, TESSEUR I, HOFKER MH, HAVEKENS LM and VAN LEUVEN F. No evidence for cholinergic problems in apolipoprotein E knockout and apolipoprotein E4 transgenic mice. Neuroscience 9, 411-418 2000.

TESSEUR I, VAN DORPE J, BRUYNSEELS K, BRONFMAN F, SCIOT R, VAN LOMMEL and VAN LEUVEN F. Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human Apolipoprotein E4 in neurons of brain and spinal cord. Am. J. Pathol. 157, 1495-1510 2000.

TCHERPAKOV, M. BRONFMAN FC, CONTICELLO SG, VASKOVSKY A, LEVY Z, NIINOBE M, YOSHIKAWA K, ARENAS E, FAINZILBER M. The p75 neurotrophin receptor interacts with multiple MAGE proteins. J. Biol. Chen. 277 49101-49104. 2002.

GILLISEN C, DE GROOT JJ, BRONFMAN F, VAN LEUVEN F, VERBRUGGEN AM, BORMANS GM. Evaluation of 18F-FA-4 and 11C-PIPZA-4 as radioligands for the in vivo evaluation of the high affinity choline uptake system. J. Nucl.Med. 44 269-275. 2003. 44 269-275. 2003

BRONFMAN FC, TCHERPAKOV M, JOVIN T, FAINZILBER M. Ligand-induced internalization of the p75 neurotrophin receptor: a slow route to the signaling endosome. J. Neurosci. 23(8) 3209-3220 2003.

BRONFMAN FC & FAINZILBER M. Multi-Tasking by the p75 neurotrophin receptor Sortilin things out? EMBOReports. 5 867-871 2004.

FUENZALIDA KM, AGUILERA MC, PIDERIT DG, RAMOS PC, CONTADOR D, QUIÑONES V, RIGOTTI A,BRONFMAN FC, BRONFMAN M. Peroxisome Proliferator-Activated receptor gamma is a novel target of the Nerve Growth Factor Signaling Pathway in PC12 cells. J. Biol. Chem, 280 (10) 9604-9 2005.

URRA S, ESCUDERO CA, RAMOS P, LISBONA F, ALLENDE E, COVARRUBIAS P, PARRAGUEZ JI, ZAMPIERI N, CHAO MV, ANNAERT W, BRONFMAN FC. Membrane bound carboxyterminal fragments of p75 neurotrophin receptor are generated by the activation of TrkA and internalized to endosomes for g-secretase mediated processing. J. Biol Chem 282 (10) 7606-1, 2007.

BRONFMAN FC, ESCUDERO CA, WEIS J, KRUTTGEN A. Endosomal transport of neurotrophins: roles in signaling and neurodegenerative diseases Dev Neurobiol 67(9) 1183-203 2007.

SANDOVAL M, SANDOVAL R, ULRICH T, SPILKER C, SMALLA KH, MARENGO JJ, CALDERON R, SAAVEDRA V, HEUMANN R, BRONFMAN FC, GARNER CC, GUNDELFINGER ED, WYNEKEN U. Antagonistic effects of TrkB and p75NTR on NMDA receptor currents in postsynaptic densities transplanted into Xenopus oocytes. J Neurochem 101 (6) 1672-84 2007.

FUENTEALBA RA, BARRIA MI, LEE, J, CAM J, ARAYA C, ESCUDERO CA, INESTROSA NC, BRONFMAN FC, BU G and MARZOLO MP. ApoER2 increases APP processing and Ab production, while decreasing APP endocytosis: Possible role in APP lipid raft partitioning and g-secretase activation. Mol Neurodegener 2(1):14 2007.

BRONFMAN FC. Metalloproteases and gamma-Secretase: New Membrane Partners Regulating p75 Neurotrophin Receptor Signaling? J. Neurochem. 103(Suppl1)   91-104 2007.

BRONFMAN FC, KAPON R. Commuting within the cell – mind the GAPs. EMBO Report 8 1-5 2007.

ALVAREZ AR, KLEIN A, CASTRO J, CANSINO GI, MOSQUEIRA M, VARGAS LM, YEVENES LF, BRONFMAN FC, ZANLUNGO S. Imatinib therapy blocks cerebellar apoptosis and improves neurological symptoms in a mouse model of Niemamm-Pick type C disease. Faseb J. 10 3617-27. 2008

LAZO OM, MAUNA J, INESTROSA NI, BRONFMAN FC. Retrograde Neurotrophic signalling support phenotypic differentiation but not survival of Cholinergic septal neurons. Mol Neurodegener. 19;5.5 2010

GUILLERMARD V, IVANISEVIC L, GALAN GARCIA A, SCHOLTEN V, LAZO OM, *BRONFMAN FC, *SARAGOVI HU. An agonistic action mAb directed to the TrkC receptor juxtamembrane region defines a trophic hot spot, and interaction with p75 co-receptors. Dev Neurobiol. 2010 70:150-64.[*Shared corresponding authorship]

KENCHAPPA KS, CHHAVVY T, KORADE Z, URRA S, BRONFMAN FC, YOON SO, CARTER BD. p75 mediated apoptosis in sympathetic neurons involves a biphasic activation of JNK and up-regulation of TACE/ADAM17. J Biol Chem. 285 (26) 20358-66. 2010.

CABEZA C, FIGUEROA A, LAZO OM, GALLEGUILLOS C, PISSANI, CA, KLEIN A, GONZALEZ-BILLAULT C, INESTROSA NC, ALVAREZ AR, ZANLUNGO S, BRONFMAN FC. Cholinergic Abnormalities and Up-regulation of NGF Signaling in Niemann-Pick Type C Disease. Submitted (August 2011). 

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